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Nutritional joint support and pain relief combined. Helps maintain joints and connective tissue MSM inhibits pain impulses, lessens inflammation, and reduces muscle spasms. Overview. Natural Factors MSM &Glucosamine Sulfate helps maintain the structural integrity of joints while relieving joint pain from osteoarthritis. It combines two top joint support nutrients that help the body form connective tissue for healthy joints and muscles, protect against the degeneration of cartilage, and reduce pa...