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Nervous System Support Stabilized SAMe, Capsule Form No Enteric Coating Needed Supports Joint Health Non-GMO A Dietary Supplement Vegetarian/Vegan Amino Acids Family Owned Since 1968 GMP Quality AssuredSAMe (S-adenosylmethionine), a compound native to the body, is a component of many biochemical reactions, including those that affect brain biochemistry and joint health. SAMe is critical for the synthesis of neurotransmitters, is important for energy production in the brain.